Locally advanced colorectal cancers that invade adjacent organs (i.e., T4 primary tumors) without evidence of distant metastasis account for approximately 5-15% of new colorectal cancers. There are limited multi-institutional study describing the perioperative complication rates and long-term survival of patients undergoing single organ resection after neoadjuvant chemotherapy and/or radiation versus multivisceral resections for patients with T4 colorectal cancers. Using the American College of Surgeons National Cancer Database (NCDB), we seek to analyze differential outcomes (perioperative complications and overall survival) by procedure performed, tumor details, pathological findings, chemo-radiotherapy regimens, patient demographics.
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