Defective efferocytosis, the phagocytic clearance of apoptotic cells, by macrophages is the cause of many human diseases including tumor, autoimmune diseases and atherosclerosis. Enhancing efferocytosis has potential therapeutic benefits. Many key regulators of efferocytosis have been identified, but a systematic approach to map regulators of efferocytosis in an unbiased manner on a genome-wide scale is missing. This project applies innovative genome-wide CRISPR screen to discover novel regulators of macrophage efferocytosis.
The visual cortex has a distinctive deep hierarchical organization as a result of ontogenetic and phylogenetic optimization. It is unclear what the factors are that shape this particular hierarchical organization. One factor is the compositional and hierarchical nature of our world’s appearance, which may be optimally processed by a hierarchical visual system. Another factor is the need for space and energy efficiency, which constrains the number of neurons and connections. The project will employ computational modeling to understand the contribution of these constraints to shaping the combination of breadth, depth, and skipping connections employed by primate visual cortex.
We have been studying bladder cancer in a mouse model of the disease and we are seeking to understand the molecular features of the mouse models as they relate to human bladder cancer.
Effective representations and analyses of symbolic data, such as lexical data (words) and networks (graphs), have become of great interest in recent years, due both to advancements in data collection in Natural Language Processing (NLP), and the ubiquity of social networks. Such data often has no natural numerical representation, and is typically described in terms relational expressions or as pairwise similarities. It turns out that finding numerical representations of such data in “Hyperbolic” spaces—rather than into the more familiar Euclidean spaces—is a more effective way to preserve valuable relational information.
Analyze data from one or more of the following Library Applications/Systems and create visualizations that highlight the most important findings related to our goal of supporting self-directed learning.
Finding the exact counterpart galaxies to merging black hole binaries detected in gravitational waves is one of the most pressing problems in cosmology. The redshift of the host galaxy (which has to be measured from its electromagnetic emission) combined with the luminosity distance to the gravitational wave source allows for a direct measurement of the expansion history of the Universe, an approach commonly referred to as the ‘Standard Siren’ method. To date, there are no proven techniques for accomplishing this goal.
Injury, such as falls, motor vehicle crashes, and drug overdose, is a major source of morbidity and mortality. The interaction between injury and disease is complex and mutually causative. For instance, patients with Alzheimer’s Disease or Parkinson’s Disease are known to be at heightened risk of hip fracture from falls and in turn injurious falls among these patients can drastically alter the trajectory of the disease. So far, research on injury-disease interaction has been scant and fragmented. The proposed project is aimed at uncovering the gestalt of the relations between different injuries and different diseases through a data science approach.