Decoding elements of mouse behavior that reveal vigilance during exploration
Decoding behavioral signifiers for the brain state of vigilance can have far reaching implications for understanding the neural basis for actions and identifying disease. We are using high resolution video recordings of mice as they navigate a maze but have access to very few pre-determined behavioral signifiers. Several recent publications implemented computer vision to extract a variety of previously unreachable aspects of behavioral analysis, including animal pose estimation and distinguishable internal states. These descriptions allowed for the identification and characterization of dynamics, which then revealed an unprecedented richness to the behaviors that determine decision making. Applying such computational approaches mice during exploration and in the context of behaviors that have been validated to measure choice and memory can reveal dimensions of behavior that predict or even determine psychological constructs like vigilance. We are also obtaining neural signal data, which can be aligned with the behavioral signifiers. DSI scholars would use pose estimation analysis to evaluate behavioral signifiers for choice and memory and relate it to our real time concurrent measures of neural activity and transmitter release. The students would also have opportunity to examine the effect of disease models known to impair performance on our maze task on any identified signifier.
This is an UNPAID research project.
- Professor: Alex, Dranovsky
- Center/Lab: Psychiatry / Neuroscience / New York State Psychiatric Institute
- Location: Kolb Annex 1st floor
- My lab is interested in how the brain encodes stressful and enriching experiences on molecular, cellular, circuit, and behavioral levels and why these experiences have such persistent effects for mental health.
- Earliest starting date: 2022-09-21
- End date: 2024-11-09
- Number of hours per week of research expected during Fall 2022: ~12
- Skill sets: MATLAB, Python, R
- Student eligibility:
freshman, sophomore, junior, senior, master’s
- International students on F1 or J1 visa: eligible
- Academic Credit Possible: Yes